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A range of BioTomo bone repair and regeneration materials (a); platelets of bone like calcium phosphate nanopowders (b); interconnected pore structure of the biotomo BioAlmog material (c). |
Technical Progress
Third Party Verified Proof of Concept studies:
• Characterisation: the structure, morphology, chemistry, purity, homogeneity, physical and chemical properties and in vitro dissolution characteristics of all materials.
• Both independent third party and in-house mechanical testing and integrity analysis.
• Micro-adhesion and nano-hardness testing.
• Wear and tribological testing of the nano-coated implants.
• In vitro cell culture studies (osteoclasts and osteoblasts).
• Simulated Body Fluid (Biocompatibility) tests.
• Incorporation of MSC, proteins and other biogenic additives-preliminary analyses.
• In vitro dissolution studies of slow drug delivery devices.
• Small animal trials of the bone grafts and drug delivery structures.
• Preliminary large animal trials.
• Long bone replacement designs and prototype production.
• Application of nanocoatings to orthopaedic and dental implants and surgical devices.
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